Substance Interaction Checker
Check potential interactions between 25 substances — smartshop products, medications, and recreational drugs. 50+ interaction pairs with safety ratings.
Risk Levels
Common Dangerous Combinations
Frequently Asked Questions
Can I combine magic truffles with SSRIs?
No. SSRIs (like sertraline, fluoxetine, paroxetine) block or reduce psychedelic effects and risk serotonin syndrome. You should stop SSRIs at least 2 weeks before using psilocybin, but only under medical supervision — never stop antidepressants without consulting your doctor.
Is it safe to combine kratom with alcohol?
No. Both kratom and alcohol are CNS depressants. Combining them significantly increases the risk of respiratory depression, nausea, and loss of consciousness. This combination should be avoided.
What is serotonin syndrome?
Serotonin syndrome is a potentially life-threatening condition caused by excess serotonin activity in the nervous system. Symptoms include agitation, rapid heart rate, high blood pressure, dilated pupils, muscle twitching, and hyperthermia. It's most commonly caused by combining serotonergic substances like SSRIs with MAOIs, kanna, MDMA, or ayahuasca.
Can I take kanna if I'm on antidepressants?
No. Kanna (Sceletium tortuosum) is a natural serotonin reuptake inhibitor. Combining it with SSRIs, SNRIs, or MAOIs can cause serotonin syndrome, which can be fatal. Do not combine kanna with any antidepressant medication.
How accurate is this interaction checker?
This tool covers 50+ known interaction pairs based on pharmacological research and harm reduction resources. However, it does not cover all possible combinations. Individual factors like body weight, metabolism, dosage, and health conditions also affect interactions. Always consult a healthcare professional when in doubt.